EditverseSystematic review and meta-analysis
from $1,800See levels and order
This service delivers a systematic review with meta-analysis as a submission-ready manuscript with its full audit trail. It is for clinicians, guideline groups and postgraduate researchers who have a focused question and need the review done to the methods journals and peer reviewers check.
Work runs in a fixed order: protocol, search, screening, extraction, risk of bias, synthesis, certainty rating, manuscript. You approve the protocol before any search is run.
Specification
- You provide
- The review question in PICO form, the databases your institution can access, any existing protocol or registration, and your preferred target journal.
- We do
- Write the protocol, build and run the search strategies, screen titles and full texts, extract data, assess risk of bias, pool the results, rate certainty and write the manuscript.
- You receive
- PROSPERO-ready protocol, full search strategies, PRISMA flow diagram, extraction sheet, RoB 2 or ROBINS-I tables, forest and funnel plots, analysis code, manuscript and completed PRISMA checklist.
- Reporting standard
- PRISMA 2020 (27-item checklist and flow diagram). Risk of bias by RoB 2 (2019) for randomised trials and ROBINS-I (2016) for non-randomised studies. Certainty of evidence by GRADE. Methods follow the Cochrane Handbook, version 6.5.
- Turnaround
- 4 to 6 weeks.
- Revision rounds
- 1 round.
- Team
- A subject-matter expert in the clinical field, a medical writer trained in evidence synthesis and a statistician for the pooled analysis.
Levels by number of included studies
All three levels follow the same method. The level depends on how many studies meet the inclusion criteria, which is known after full-text screening and estimated at the protocol stage.
| Included | Basic $1,800 | Advanced $2,800 | Premium $3,800 |
|---|---|---|---|
| Included studies | Up to 15 | 16 to 40 | 41 to 80 |
| Protocol, searches, screening, extraction and PRISMA flow diagram | |||
| Risk of bias tables and figures | |||
| Pooled analysis with forest and funnel plots, heterogeneity and sensitivity analysis | |||
| Subgroup analyses and meta-regression | |||
| GRADE certainty rating | Where appropriate | Where appropriate | Full evidence profile |
| Manuscript, PRISMA checklist and analysis code |
All levels include 1 revision round.
Reviews with more than 80 included studies and network meta-analyses are by quote.
How the work is checked
- Protocol fixed and approved by you before searching; later changes are recorded as dated amendments and reported in the manuscript.
- Search strategies saved in full for every database with run dates and record counts, so the flow diagram can be reproduced.
- Screening and extraction decisions logged with reasons for exclusion at full text.
- Data-to-plot check: effect sizes in the forest plots are traced to the extraction sheet and to the source papers, and the analysis code is rerun from a clean session.
- PRISMA 2020 checklist completed with page locations and attached; reference list verified against PubMed or DOI records.
Not included
Registering the protocol on PROSPERO under your account, subscription database access fees and purchase of paywalled full texts are handled by you. Network meta-analysis is scoped separately.
Ordering and payment
Select the level that matches your expected study count and pay by invoice, or choose "Request this service" to send the question first and pay after the first draft, only if it meets your expectations; the review may be used once payment is made. If screening places the review in a different level, the difference is agreed with you before extraction starts. Official invoices and receipts are issued for grant or institutional claims. Protocol-only, search-only and larger reviews are by quote.
Questions
How do I know which level to order before screening?
A scoping search at the protocol stage gives an estimate of eligible studies. If you are unsure, send the PICO question through the quote form and the estimate is returned with the recommended level.
What happens if too few studies can be pooled?
The review is completed as a systematic review with a structured narrative synthesis, and the manuscript says why pooling was not appropriate.
Who registers the protocol?
You do, as the review lead. The protocol is supplied in the fields PROSPERO asks for, and PRISMA 2020 expects the registration number in the manuscript.
Which software is used for the analysis?
Normally R. The code and input files are delivered so that reviewers or co-authors can rerun every plot.
Part of Journal manuscripts. Related: Narrative and scoping review article and Reviewer response and revision.
Order this service
from $1,800